As an OptumRx provider, you know that certain medications require approval, or 
prior authorization (PA), to ensure that they are medically necessary and appropriate for the 
reason prescribed before they can be covered. PAs help manage costs, control misuse, and 
protect patient safety, as well as ensure the best possible therapeutic outcomes.
PA reviews are completed by clinical pharmacists and/or medical doctors who base utilization 
review decisions on sound clinical evidence and make a determination within the timeframe 
allowed by state or federal law. To ensure that a PA determination is provided to you in a timely 
manner, please submit all information needed to make a decision. Lack of information may delay 
the decision-making process and may result in a denial unless all required information is received. 
Once a review is complete, the provider is informed whether the PA request has been approved or 
denied. If denied, the provider may choose to prescribe a less costly but equally effective, alternative 
covered medication, and/or OptumRx will offer information on the process to appeal the adverse decision.
The OptumRx Pharmacy Utilization Management (UM) Program utilizes drug-specific prior 
authorization (PA) guidelines* to encompass assessment of drug indications, set guideline 
types (step therapy, PA, initial or reauthorization) and approval criteria, duration, effective 
dates and more. Guidelines are based on written objective pharmaceutical UM decision- 
making criteria** that are developed from clinical evidence from the following sources:
*Guidelines are specific to plans utilizing our standard drug lists only. Your patient’s 
prescription drug benefits may be covered under his/her plan-specific formulary for which 
these guidelines may not apply. We recommend you speak with your patient regarding 
prescription drug benefit coverage under his/her health insurance plan or call OptumRx.
** OptumRx’s Senior Medical Director provides ongoing evaluation and quality assessment of 
the OptumRx UM Program.
 
How to access the OptumRx PA guidelines:
Submitting an electronic prior authorization (ePA) request to OptumRx
ePA is a secure and easy method for submitting,managing, tracking PAs, step 
therapy and non-formulary exception requests. It enables a faster turnaround time of 
coverage determinations for most PA types and reasons.
Login to your preferred web-based portal account and select “New Request”within 
your Dashboard to submit your PA request.
 
Submitting a PA request to OptumRx via phone or fax
As part of an ongoing effort to increase security, accuracy, and timeliness of PA 
requests and determinations, OptumRx is retiring most fax numbers used for 
submitting pharmacy prior authorization requests for all plans managed by 
OptumRx, except for the following states: MA, RI, SC, and TX. We strongly 
encourage providers to submit PA requests using the ePA process as described 
above.
If providers are unable to submit electronically, we offer the following options:
Call 1-800-711-4555 to submit a verbal PA request 
View and print a PA request form
For urgent requests, please call us at 1-800-711-4555. 
(Hours: 5am PST to 10pm PST, Monday through Friday.)